Urva S, Coskun T, Loh MT, Du Y, Thomas MK, et al
A BMI of 27 or higher with weight-related health conditions (like high blood pressure or high cholesterol)
reported that embryonic glucagon-expressing cells also expressed PC1/3 and that the level of PC1/3 expression decreased with age ( ARX and DNMT1 , are differentially expressed across alpha-cell subpopulations, in which pseudotime analysis suggested that certain subpopulations are more mature than others ( PCSK1 (gene name for PC1/3) ( PCSK1 -expressing alpha-cell subpopulation in response to intra-islet GLP-1R signaling ( TOP2A , MKI67 , CENPF , BIRC5 , and CDK1 ), suggesting that one of these subpopulations, albeit the smaller subpopulation, of alpha-cells may constitute proliferating alpha-cells ( TOPA1 , CENPF , and AURKB ( Further technical advances have enabled researchers to validate single-cell transcriptomes with direct functional correlates in the same cell, resulting in more precise measures of alpha-cell heterogeneity
K., Christensen, E., Christensen, M., Norgaard-Petersen, B., Schwartz, M., and Skovby, F
N Engl J Med 373:22472257 Marso SP, Daniels GH, Brown-Frandsen K, Kristensen P, Mann JF, Nauck MA, Nissen SE, Pocock S, Poulter NR, Ravn LS, Steinberg WM, Stockner M, Zinman B, Bergenstal RM, Buse JB (2016) LEADER Steering Committee
